https://amrsjournals.com/index.php/jamrmhss/issue/feed 2026-08-27T14:42:48+07:00 Asian Multicultural Research Studies editor@amrsjournals.com Open Journal Systems <p><strong>Journal of Asian Multicultural Research for Medical and Health Science Study (JAMRMHSS) </strong>ISSN <a href="https://portal.issn.org/resource/ISSN-L/2708-972X">2708-972X</a> is an international platform for scholars to publish research report, article review, and short communication. <strong>JAMRMHSS</strong> covers all the areas of research activities in all fields of Medical and Health Science such as Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Home care, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy &amp; Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.</p> https://amrsjournals.com/index.php/jamrmhss/article/view/1062 2026-08-25T15:18:46+07:00 Khairani Fitri khairaniii@gmail.com Marwan Saad Azzubaidi marwannn@gmail.com Nurul Huda Mat Hassan nurull2122@gmail.com Tetty Noverita Khairani tettty@gmail.com

<div><span lang="EN">Breast cancer is one of the most prevalent malignancies globally, and resistance to standard therapies such as tamoxifen and trastuzumab poses significant treatment challenges. Lotus (<em>Nelumbo nucifera</em>) leaves contain bioactive compounds, including kaempferol, quercetin, and neferine, which exhibit promising anticancer properties through multi-target mechanisms. This review aims to synthesize preclinical evidence on the anticancer potential of lotus leaves and compare their effectiveness and molecular pathways with other herbal extracts tested in breast cancer models. A narrative review of studies published between 2015 and 2024 was performed using PubMed and ResearchGate databases. Eligible studies included in vitro, in vivo, or silico models evaluating lotus leaves or related herbal extracts against breast cancer. The selection process adhered to the PRISMA 2020 guidelines. Lotus leaf extracts demonstrated approximately 85% inhibition of migration and metastasis in breast cancer models via multiple pathways, including TGF-β/SMAD, ERK, PI3K/Akt, and apoptotic signaling. These effects were validated in xenograft and metastatic models and, in some cases, surpassed the efficacy of standard agents. Comparatively, <em>Nymphaea mexicana</em> achieved the highest inhibition (~88%) but lacked detailed mechanistic data, while lotus seedpod extract (80%) showed activity against radioresistant models via DNA repair inhibition. Lotus leaves exhibit potent and broad-spectrum anticancer activity through multi-pathway mechanisms, positioning them as promising candidates for integrative breast cancer therapy. Further research should prioritize standardized extract preparation, dose–response studies, and clinical validation to translate preclinical findings into therapeutic applications</span></div>

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