The Impact of Alcohol Consumption Duration and Types on Colorectal Cancer: Insights from a Cross-Sectional Study in Medan, Indonesia

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Irma Yanti Rangkuti


Colorectal cancer is the third most common type of cancer in the world, in Indonesia it is in the fourth highest position. Nearly 1 million deaths a year were due to colorectal cancer. Alcohol increases the risk of developing colorectal cancer. This study aims to analyze differences in duration of alcohol consumption in people with and without colorectal cancer and to analyze the relationship between type of alcohol and the incidence of colorectal cancer. The research was carried out at the Digestive Surgery Polyclinic, H. Adam Malik Hospital, Medan. Using primary and secondary data involving 31 subjects. Subjects aged 30-80 years, 21 men, 10 women, 80.6% suffered from colorectal cancer. 28 people (90.3%) consumed type A alcohol the most. The mean duration of alcohol consumption in colorectal cancer sufferers and those without colorectal cancer was 14.76 ± 3.33 years and 11.00 ± 3.688 years. There is a difference in the duration of alcohol consumption in people with and without colorectal cancer, and the type of alcohol consumed is not related to the incidence of colorectal cancer.


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Rangkuti, I. Y. (2024). The Impact of Alcohol Consumption Duration and Types on Colorectal Cancer: Insights from a Cross-Sectional Study in Medan, Indonesia. Journal of Asian Multicultural Research for Medical and Health Science Study, 5(1), 1-6.


Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2017). Global patterns and trends in colorectal cancer incidence and mortality. Gut, 66(4), 683–691.

Badan Pusat Statistik Indonesia. (2022). Konsumsi Alkohol Oleh Penduduk Umur ≥ 15 Tahun Dalam Satu Tahun Terakhir (Liter Per Kapita), 2020-2022.

Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., Scotti, L., Jenab, M., Turati, F., Pasquali, E., Pelucchi, C., Galeone, C., Bellocco, R., Negri, E., Corrao, G., Boffetta, P., & La Vecchia, C. (2015). Alcohol consumption and site-specific cancer risk: A comprehensive dose-response meta-analysis. British Journal of Cancer, 112(3), 580–593.

Dahlan, M. S. (2010). Mendiagnosis dan Menatalaksana 13 Penyakit Statistik: Disertai Aplikasi Program Stata. Sagung Seto.

Hastono, S. P. (2007). Analisis Data Kesehatan. Universitas Indonesia.

Hossain, M. S., Karuniawati, H., Jairoun, A. A., Urbi, Z., Ooi, D. J., John, A., Lim, Y. C., Kibria, K. M. K., Mohiuddin, A. K. M., Ming, L. C., Goh, K. W., & Hadi, M. A. (2022). Colorectal Cancer : A Review of Carcinogenesis , Global. Cancer, 14(1732), 1–25.

Indonesia, M. P. R. (2012). Peraturan Menteri Perindustrian Republik Indonesia Tentang Pengendalian dan Pengawasan Industri Minuman Beralkohol.

Johnson, C. H., Dejea, C. M., Edler, D., Hoang, L. T., F., A., Santidrian, Felding, B. H., Cho, K., Wick, E. C., M., E., Hechenbleikner6, Winnie Uritboonthai1, Laura Goetz7, Robert A. Casero Jr8, D. M., & Pardoll8, James R. White9, Gary J. Patti5, Cynthia L. Sears2, 8, 11, and G. S. (2015). Metabolism Links Bacterial Biofilms and colon Carcinogenesis. Cell Metabolism, 21(6). 04.011.Metabolism

Johnson, C. H., Golla, J. P., Dioletis, E., Singh, S., Ishii, M., Charkoftaki, G., Thompson, D. C., & Vasiliou, V. (2021). Molecular mechanisms of alcohol-induced colorectal carcinogenesis. Cancers, 13(17), 1–17.

Kamphorst, J. J., Chung, M. K., Fan, J., & Rabinowitz, J. D. (2014). Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism, 2(1), 1–8.

Lin, T. C., Chien, W. C., Hu, J. M., Tzeng, N. S., Chung, C. H., Pu, T. W., Hsiao, C. W., & Chen, C. Y. (2020). Risk of colorectal cancer in patients with alcoholism: A nationwide, population-based nested case-control study. PLoS ONE, 15(5), 1–12.

Marchitti, S. A., Brocker, C., Stagos, D., & Vasiliou, V. (2008). Non-P450 Aldehyde Oxidizing Enzymes: The Aldehyde Dehydrogenase Superfamily. Expert Opin Drug Metab Toxicol, 4(6), 1–7.

Park, S. Y., Wilkens, L. R., Setiawan, V. W., Monroe, K. R., Haiman, C. A., & Le Marchand, L. (2019). Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study. American Journal of Epidemiology, 188(1), 67–76.

Rossi, M., Anwar, M. J., Usman, A., Keshavarzian, A., & Bishehsari, F. (2018). Colorectal cancer and alcohol consumption—populations to molecules. Cancers, 10(2).

Sawicki, T., Ruszkowska, M., Danielewicz, A., Nied´zwiedzka, E., Przybyłowicz, T. A., & E., K. (2021). A Review of Colorectal cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis. Cancers, 13(2025), 1–23.

Seitz, H. K., & Stickel, F. (2007). Molecular mechanisms of alcohol-mediated carcinogenesis. Nature Reviews Cancer, 7(8), 599–612.

Varghese, J., & Dakhode, S. (2022). Effects of Alcohol Consumption on Various Systems of the Human Body: A Systematic Review. Cureus, 14(10), 8–13.

WHO. (2020). Colorectal Cancer. International Agency for Research on Cancer.

WHO. (2021). Cancer incident in Indonesia. International Agency for Research on Cancer.

Wong, M. C. S., Huang, J., Lok, V., Wang, J., Fung, F., Ding, H., & Zheng, Z. J. (2021). Differences in Incidence and Mortality Trends of Colorectal Cancer Worldwide Based on Sex, Age, and Anatomic Location. Clinical Gastroenterology and Hepatology, 19(5), 955-966.e61.

Yoshii, Y., Furukawa, T., Saga, T., & Fujibayashi, Y. (2015). Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application. Cancer Letters, 356(2), 211–216.