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Until now, HIV infection is still a global health problem. Handling of HIV infection cases still faces many problems due to various factors. As a result of these factors can also affect the quality of life of PLWHA. The purpose of this study was to analyze the influence of factors from knowledge, attitudes, stigma and family support on the quality of life of PLWHA at the Community health center Service of Teladan in 2020. This study used an analytic survey design with a cross-sectional approach. The sample size in the study was 93 people. The measuring instrument used is a questionnaire. The bivariate analysis used was the Chi-square test and the multivariate with the multivariable logistic regression test. A total of 72 respondents (77.4%) were male and 63 respondents (67.4%) were adults. From the results of the multivariate analysis, the sig values of knowledge (p = 0.013), attitudes (p = 0.045), stigma (p = 0.045) and family support (p = 0.001) were obtained. It was found that there was an influence of knowledge, attitudes, stigma and family support factors on the quality of life of PLWHA. From the results of this study, it is hoped that it can improve services to PLWHA and provide understanding about HIV-AIDS to patients, families and also the community in order to reduce stigma and discrimination against PLWHA
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